Substituted benzoazole PDE4 inhibitors for treating pulmonary and cardiovascular disorders

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专利权人:

deCODE genetics ehf

发明人:

Kiselyov, Alexander,Gurney, Mark,Rao, Munagala,Burgin, Alex,Singh, Jasbir

申请号：

AU2008326399

公开号：

AU2008326399C1

申请日:

2008.11.20

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

The invention relates to substituted benzothiazoles, benzoxazoles - and their counterparts having pyridine and pyrimidine rings replacing the benzene ring - that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula (I), in which A and B are carbocycles or heterocycles. A particular embodiment is Formula (II).

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