GASPAR, RENEE C.,SHUGHRUE, PAUL J.,WANG, FUBAO,WANG, WEIRONG,ZHANG, NINGYAN,ZHAO, WEI-QIN,MCCAMPBELL, ALEXANDER,XU, MIN
申请号：
EP11807457
公开号：
EP2593475A4
申请日:
2011.07.13
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
Disclosed are antibodies that bind amyloid beta-derived diffusible ligands, also known as ADDLs. The antibodies are selective for ADDLs, can penetrate the brain, and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with ADDLs.
