Renee C. Gaspar,Paul J. Shughrue,Fubao Wang,Weirong Wang,Ningyan Zhang,Wei-Qin Zhao,Min Xu,Alexander McCampbell
申请号：
US14326974
公开号：
US09309309B2
申请日:
2014.07.09
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to antibodies that bind amyloid β-derived diffusible ligands, also known as ADDLs. The antibodies of the invention are selective for ADDLs, can penetrate the brain, and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with ADDLs.
