YEONG SOO OH,YOU SEUNG SHIN,SANG SOO KIM,SANG YEUL HWANG,MI KYUNG YUN,SEONG RYUL HWANG,SEONG WON HONG,YONG HEE LEE,YI NA JEONG,KOO LEE
申请号：
MYPI 96004474
公开号：
MY155266A
申请日:
1996.10.28
申请国别(地区):
MY
年份:
2015
代理人:
摘要：
THE PRESENT INVENTION RELATES TO A NOVEL SELECTIVE THROMBIN INHIBITOR HAVING THE FOLLOWING FORMULA (I), WHICH IS ALSO EFFECTIVE BY ORAL ADMINISTRATION: @@ FORMULA (1) @@ IN WHICH @ R1 REPRESENTS ACETYL SUBSTITUTED WITH ARYL OR ARYLOXY, OR REPRESENTS SULFONYL SUBSTITUTED WITH SUBSTITUTED OR UNSUBSTITUTED ARYL OR N-CONTAINING HETEROCYCLIC GROUP, X REPRESENTS A GROUP OF FORMULA -NOR -N N-R5@-R3R4 @ R2 AND R3 INDEPENDENTLY OF ONE ANOTHER REPRESENT HYDROGEN CYCLOALKYL SUBSTITUTED OR UNSUBSTITUTED WITH CARBOXYL OR ALKOXYCARBONYL ARYLALKYLOXY HYDROXY OR LOWER ALKYL SUBSTITUTED OR UNSUBSTITUTED WITH CARBOXYL, ALKOXYCARBONYL OR HYDROXY, OR @ R2 AND R3 TOGETHER WITH NITROGEN ATOM TO WHICH THEY ARE ATTACHED CAN FORM A PIPERIDINE GROUP SUBSTITUTED WITH CARBOXYL OR ALKOXYCARBONYL, @ R4 REPRESENTS HYDROGEN, LOWER ALKYL OR LOWER ALKOXY, @ R5 REPRESENTS ALKANESULFONYL ALKOXYCARBONYL ALKYLCARBONYL FORMYL LOWER ALKYL ARYL SUBSTITUTED OR UNSUBSTITUTED WITH ALKOXY OR HALOALKYL OR HYDROXY-SUBSTITUTED LOWER ALKYL, @ AND @ R6 AND R7 INDEPENDENTLY OF ONE ANOTHER REPRESENT HYDROGEN, LOWER ALKYL OR AMINO,AND TO A PROCESS FOR PREPARATION THEREOF AND A PHARMACEUTICAL COMPOSITION FOR THROMBIN INHIBITION WHICH COMPRISES THE COMPOUND OF FORMULA (I) AS AN ACTIVE INGREDIENT.
