YEONG SOO OH,YOU SEUNG SHIN,SANG SOO KIM,SANG YEUL HWANG,MI KYUNG YUN,SEONG RYUL HWANG,SEONG WON HONG,YONG HEE LEE,YI NA JEONG,KOO LEE
申请号：
MYPI 20014396
公开号：
MY155273A
申请日:
1996.10.28
申请国别(地区):
MY
年份:
2015
代理人:
摘要：
THE PRESENT INVENTION RELATES TO A NOVEL SELECTIVE THROMBIN INHIBITOR HAVING THE FOLLOWING FORMULA (I), WHICH IS ALSO EFFECTIVE BY ORAL ADMINISTRATION: IN WHICH @ R1 REPRESENTS ACETYL SUBSTITUTED WITH ARYL OR ARYLOXY, OR REPRESENTS SULFONYL SUBSTITUTED WITH SUBSTITUTED OR UNSUBSTITUTED ARYL OR N-CONTAINING HETEROCYCLIC GROUP, X REPRESENTS A GROUP OF FORMULA @@ R2 AND R3 INDEPENDENTLY OF ONE ANOTHER REPRESENT HYDROGEN CYCLOALKYL SUBSTITUTED OR UNSUBSTITUTED WITH CARBOXYL OR ALKOXYCARBONYL ARYLALKYLOXY HYDROXY OR LOWER ALKYL SUBSTITUTED OR UNSUBSTITUTED WITH CARBOXYL, ALKOXYCARBONYL OR HYDROXY, OR @ R2 AND R3 TOGETHER WITH NITROGEN ATOM TO WHICH THEY ARE ATTACHED CAN FORM A PIPERIDINE GROUP SUBSTITUTED WITH CARBOXYL OR ALKOXYCARBONYL, R4 REPRESENTS HYDROGEN, LOWER ALKYL OR LOWER ALKOXY, R5 REPRESENTS ALKANESULFONYL ALKOXYCARBONYL ALKYLCARBONYL FORMYL LOWER ALKYL ARYL SUBSTITUTED OR UNSUBSTITUTED WITH ALKOXY OR HALOALKYL OR HYDROXY-SUBSTITUTED LOWER ALKYL, AND R6 AND R7 INDEPENDENTLY OF ONE ANOTHER REPRESENT HYDROGEN, LOWER ALKYL OR AMINO, AND TO A PROCESS FOR PREPARATION THEREOF AND A PHARMACEUTICAL COMPOSITION FOR THROMBIN INHIBITION WHICH COMPRISES THE COMPOUND OF FORMULA (I) AS AN ACTIVE INGREDIENT.
