#$%^&*AU2012201956A120120426.pdf#####C:\NRPonbl\DCC\SCG424 15_1 [W4/14/2012 ABSTRACT The present invention includes use of a biological response modifier (BRM) to modulate an immune response in a subject while avoiding or limiting common side-effects associate with BRM use. The BRMs of the present invention can be injected into a secondary lymphatic organ of the subject or into an area of relatively high drainage into a secondary lymphatic organ of the subject. The modulated immune response can be general or antigen-specific.