abstract the present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing an fcrn-binding domain having a fcrn-binding activity neutral ph range, immune responses to the antigen are induced. furthermore, the present inventors have discovered that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose binding activity to an antigen changes depending on ion concentration conditions and containing a fcrn-binding domain having fcrn-binding activity in a neutral ph range, immune responses to the antigen are induced, and also the antigen-binding molecule has cytotoxicity or antiproliferative action against cancer cells, foreign biological species, or such that expression of the antigen to which the antigen-binding molecule binds. patent abstract: "target antigen immune response inducing antigen binding molecule". The present invention relates to the inventors' finding that in living organisms that have received an antigen-binding molecule containing an antigen-binding domain whose antigen-binding activity changes depending on ion concentration conditions and containing an antigen-binding domain. of fcrn having fcrn binding activity in a neutral ph range, immune responses to antigen are induced. further, the present inventors have found that in living organisms that have received an antigen binding molecule containing an antigen binding domain whose antigen binding activity changes depending on ion concentration conditions and containing an fcrn binding domain having active activity. binding to fcrn in a neutral ph range, immune responses to antigen are induced, and also the antigen binding molecule has cytotoxicity or antiproliferative action against cancer cells, foreign biological species or the like expressing the antigen to which the
