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Compounds and Methods for Enhancing innate immune responses
专利权人:
GLAXOSMITHKLINE LLC
发明人:
申请号:
ARP120103945
公开号:
AR088793A1
申请日:
2012.10.22
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
These compounds are used to treat viral infections. 1. Claim 1: a compound with a salt structure acceptable according to formula (1) or formula, the structure of which is as follows:X830808,Xs degrees 8311;X831222 is selected independently from n, NH, s, O, C, CH, or ch832222;X3,X830909,X8310 is selected independently from n, C, or CH; Z is selected from the link, - C (or),or C₁₋₆ alkylene;R1 is selected from the group consisting of hydrogen, R1 2,-R830808,-R (R)-OR⁹ (R¹⁵) ₘ,and halogen; R² is selected from the group consisting of hydrogen, C₁₋₆ alkyl,C₁₋₆ alkoxy,-R1,-R830808,C (O) R-R⁹R¹²,-R⁹R¹³,-R⁹R¹⁴,-C (O) R-R (R)-OR⁹ (R¹⁵) ₘ,- Oran 3,-R S (O)-S (O) Ra. Halogen, nitrogen, sulfur amide, sulfur, sulfur oxide, arilo c832318321;y cicloalquilo C2. In this case, R2 group can be replaced by one to three R2 groups; 1R³ is selected from the group consisting of hydrogen, C₁₋₆ alkyl,C₁₋₆ alkoxy,-R1,-R830808,C (O) R-R⁹R¹²,-R⁹R¹³,-R⁹R¹⁴,-C (O) R-R (R)-OR⁹ (R¹⁵) ₘ,- Oran 3,a. Halogen, nitrogen, sulfur amide, sulfur, sulfur oxide, arilo c832318321;y cicloalquilo CIn this case, R3 group can be replaced by 1 to 3 R1 groups; 1R⁴ is optionally absent or selected from consisting of hydrogen, C₁₋₆ alkyl,-R (R)-OR⁹ (R¹⁵) ₘ,-R⁹R¹⁰,-C (O) R-C (O) Ra. Halogen and cyclopentanediol c832318321; andR⁵ is selected from the group that hydrogen, C₁₋₆ alkyl,-C (O) R-R⁹R¹²,-R (R)-OR⁹ (R¹⁵) ₘ,-R830808,a. Keywords halogen and nitrogen; r8310 was selected from hydrogen group, tar c83231;C₁₋₆ alkoxy,-R1,-R830808,C (O) R-R⁹R¹²,-R⁹R¹³,-R⁹R¹⁴,-C (O) R-R (R)-OR⁹ (R¹⁵) ₘ,- Oran 3,a. Halogen, nitrogen, sulfur amide, sulfur, sulfur oxide, arilo c832318321;y cicloalquilo CIn this case, the r8310 group can be replaced by one to three R1 groups optionally; 1R⁷ is selected from the group consisting of hydrogen, C₁₋₆ alkyl,-R (R)-OR⁹ (R¹⁵) ₘ,hal geno -C (O) R-R⁹R¹²,nitrile, and -R¹⁴;R⁸ is independently selected from the group consisting of hydrogen and C₁₋₆ alkyl;R⁹ is C₁₋₆ alkyl;R¹⁰ is aryl C₄₋₁₄;R¹¹ is select
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