To solve conventional problems of fibrogenesis on the surface of a device, lack of oxygen supply to cells, and cell bias, in an immunoisolation device using a porous membrane as an immunoisolation membrane.SOLUTION: Provided is an immunoisolation device 1 directed to implantation, comprising an immunoisolation membrane 10, as well as an oxygen supply mechanism 20 and three-dimensional cell support 30 which were sealed inside of the immunoisolation membrane 10 by a physical sealant or a biocompatible adhesive, or a combination thereof, the immunoisolation membrane 10 being a porous membrane provided with a hydrophilic layer on the outer surface, and the oxygen supply mechanism 20 enabling oxygen supply to cells 40 supported by the three-dimensional cell support 30 through an oxygen permeable membrane 21.SELECTED DRAWING: Figure 1【課題】多孔質膜を免疫隔離膜として用いる免疫隔離デバイスにおいて、デバイス表面での線維化、細胞への酸素供給不足、及び細胞の偏りという従来の問題を解決することを目的とする。【解決手段】移植向けの免疫隔離デバイス１であって、免疫隔離膜１０と、免疫隔離膜１０の内側に物理的な封止もしくは生体適合性接着剤又はそれらの組合せによって密封された酸素供給機構２０及び３次元細胞支持体３０とを備え、免疫隔離膜１０は、外表面に親水層を備える多孔質膜であり、酸素供給機構２０は、３次元細胞支持体３０に支持される細胞４０に対し酸素透過膜２１を介して酸素を供給可能としたことを特徴とする。【選択図】図１
