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COMPOSICIONES FARMACEUTICAS QUE CONTIENEN UN INHIBIDOR DE DGAT1
专利权人:
NOVARTIS AG
发明人:
WEN, HONG,KUMARAPERUMAL, NATRAJAN,NAUSE, RICHARD
申请号:
PE0008372013
公开号:
PE03752014A1
申请日:
2011.10.14
申请国别(地区):
PE
年份:
2014
代理人:
摘要:
Refers to a Pharmaceutical composition, comprising: a) a compound of formula (i) as the acid (4 - (4 - [5 - (6 - trifluoro methyl - amino - pyridin-3-yl) pyridin-2-yl]} - cyclohexyl phenyl) - acetic acid or a Salt the same, b) one or more surfactants Lubricants such as LAURYL SULFATE s Hate, Stearic acid, Palmitic acid, among others, in a number of 0.1% to 5% by weight of the composition, (c) one or more Binders with Dry DISINTEGRATING properties such as polyethylene glycols, pregelatinized Starch, chitosan, Starch, among others, in an amount of 5% to 15% by weight of the composition, (d) one or more fillers such as a mixture of Cellulose m Icrocristalina and lactose anhydrousWhere the proportion of Cellulose microcriatalina lactose is between 1: 1 and 1: 1), and one or more disintegrating such as croscarmellose Sodium, cross-linked polyvinyl pyrrolidone, Sodium Starch glycolate.It also relates to a Preparation Process which includes the steps of: mixing the compound of formula (i) with an excipient, Compacting Roller, grinding the mixture, lubricate the resulting mixture and compress the resulting mixture in a Solid oral dosage formREFERIDA A UNA COMPOSICION FARMACEUTICA, QUE COMPRENDE: a) UN COMPUESTO DE FORMULA (I) TAL COMO EL ACIDO (4-{4-[5-(6-TRIFLUORO-METIL-PIRIDIN-3-IL-AMINO)-PIRIDIN-2-IL]-FENIL}-CICLOHEXIL)-ACETICO O UNA SAL DEL MISMO, b) UNO O MAS TENSOACTIVOS CON PROPIEDADES LUBRICANTES TALES COMO LAURIL-SULFATO DE SODIO, ACIDO ESTEARICO, ACIDO PALMITICO, ENTRE OTROS, EN UNA CANTIDAD DE 0.1% A 5% EN PESO DE LA COMPOSICION, c) UNO O MAS AGLUTINANTES SECOS CON PROPIEDADES DESINTEGRANTES TALES COMO POLIETILENGLICOLES, ALMIDON PREGELATINIZADO, QUITOSANO, ALMIDON, ENTRE OTROS, EN UNA CANTIDAD DE 5% A 15% EN PESO DE LA COMPOSICION, d) UNO O MAS RELLENOS TALES COMO UNA MEZCLA DE CELULOSA MICROCRISTALINA Y LACTOSA ANHIDRA, DONDE LA PROPORCION DE CELULOSA MICROCRIATALINA A LACTOSA ES ENTRE 1:5 Y 1:1, e) UNO O MAS DESINTEGRANTES TALES COMO CROSCARMELOSA DE SODIO, PO
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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