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СОСТАВЫ, ПРИГОДНЫЕ ДЛЯ ВАКЦИН, ПОЛУЧАЕМЫХ СУШКОЙ РАСПЫЛЕНИЕМ
专利权人:
ПЭКСВЭКС; ИНК. (US)
发明人:
ПАТЕЛ Эмиш А. (US),ШАБРАМ Пол У. (US)
申请号:
RU2013143149/15
公开号:
RU2013143149A
申请日:
2012.02.24
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The composition of the spray-drying comprising viral particles, sucrose and tsiklodekstrin.2. Composition according to claim 1, wherein said viral particles are adenovirus chastitsy.3. Composition according to claim 1, wherein said viral particles comprise an adenoviral vector that is replication-kompetentnym.4. Composition according to claim 1, wherein the cyclodextrin is α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin or their smes.5. Composition according to claim 1, wherein the total amount of sucrose and cyclodextrin is from about 5% by weight. to about 15% by weight. from said sostava.6. Composition according to claim 1, further comprising ekstsipient.7. Composition according to claim 1, further comprising raffinose, mannitol, lactose, starch or smes.8. Composition according to claim 1, further comprising spraying sredstvo.9 increases. The composition of claim 1 further comprising maltodextrin, lactose, talc, triethyl citrate, gelatin or smes.10. Composition according to claim 1, further comprising boosting means for spraying an amount of about 3% by weight. to about 15% mas.11. Composition according to claim 1, further comprising a surfactant veschestvo.12. Composition according to claim 1, further comprising polysorbates, poloxamers or smes.13. Composition according to claim 1, further comprising a surface-active agent in an amount from about 0.05% by weight. up to about 1% mas.14. Composition according to claim 1 is an aqueous sostav.15. Composition according to claim 1, wherein the total solids content of the composition is less than about 30% mas.16. Composition according to claim 1, wherein the total solids content of the composition is from about 5% by weight. to about 25% mas.17. The spray dried powder containing viral h1. Состав для сушки распылением, содержащий вирусные частицы, сахарозу и циклодекстрин.2. Состав по п.1, где указанные вирусные частицы представляют собой аденовирусные частицы.3. Состав по п.1, где указанные вирусные частицы содержат
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