Ofitserova Ekaterina Sergeevna (RU),Офицерова Екатерина Сергеевна (RU),Shklyarenko Artem Aleksandrovich (RU),Шкляренко Артем Александрович (RU),Chernyshev Vladimir Vasilevich (RU),Чернышев Владимир Ва
申请号：
RU2019130703
公开号：
RU0002708892C1
申请日:
2019.09.26
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to organic and medical chemistry and specifically to novel compounds of the class of heterocyclic systems – derivatives of 2-aryl-6-(methylthio)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine, of general formula I, where R=H, R1=phenyl (Ia) – 6-(methylthio)-2-phenyl-4-chloro-2H-pyrazolo[3,4-d]pyrimidine； R=H, R1=2-bromophenyl (1b) – 2-(2-bromophenyl)-6-(methylthio)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine； R=H, R1=2-methylphenyl (Ic) – 6-(methylthio)-2-(2-methylphenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine； R=H, R1=2-methoxyphenyl (Id) – 6-(methylthio)-2-(2-methoxyphenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine； R=H, R1=2-nitrophenyl (Ie) – 6-(methylthio)-2-(2-nitrophenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine； R=H, R1=3-bromophenyl (If) – 2-(3-bromophenyl)-6-(methylthio)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine； R=H, R1=3-methylphenyl (Ig) – 6-(methylthio)-2-(3-methylphenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine； R=H, R1=3-methoxyphenyl (Ih) – 6-(methylthio)-2-(3-methoxyphenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine； R=H, R1=3-nitrophenyl (Ii) – 6-(methylthio)-2-(3-nitrophenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine； R=H, R1=4-bromophenyl (Ij) – 2-(4-bromophenyl)-6-(methylthio)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine； R=H, R1=4-methylphenyl (Ik) – 6-(methylthio)-2-(4-methylphenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine； R=H, R1=4-methoxyphenyl (Il) – 6-(methylthio)-2-(4-methoxyphenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine. Invention also relates to a method of producing a compound of formula (I).EFFECT: obtaining novel heterocyclic compounds having antimicrobial activity.2 cl, 1 dwg, 13 exИзобретение относится к области органической и медицинской химии, а именно к новым соединениям класса гетероциклических систем - производным 2-арил-6-(метилтио)-4-хлор-2H-пиразоло[3,4-d]пиримидина, общей формулы I, где R=H, R1=фенил (Ia) - 6-(метилтио)-2-фенил-4-хлор-2H-пиразоло[3,4-d]пиримидин； R=H, R1=2-бромфенил (1б) - 2-(2-бромфенил)-6-(метилтио)-4-хлор
