Rotavirus preparations with excess calcium ions and high viscosities that ensure vaccine viability at elevated temperatures

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专利权人:

发明人:

PULLIAM BRIAN

申请号：

IN2201/DELNP/2014

公开号：

IN2014DN02201A

申请日:

2014.03.24

申请国别(地区):

IN

年份:

2015

代理人:

摘要：

The invention describes a set of formulations and methods that provide for stabilization of viruses in liquid and dried states. In particular formulations include Rotavirus preparations with excess Ca2+ and high viscosities that ensure infective potency at elevated temperatures. Methods include bulk purification of Rotavirus from cell culture and administration of formulations as vaccines including components for gastric neutralization.

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