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ROTAVIRUS PREPARATIONS WITH EXCESS CALCIUM IONS AND HIGH VISCOSITIES THAT ENSURE VIABILITY AT ELEVATED TEMPERATURES
专利权人:
Brian L. Pulliam
发明人:
Brian L. Pulliam
申请号:
US14347237
公开号:
US20140356396A1
申请日:
2012.08.25
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The invention describes a set of formulations and methods that provide for stabilization of viruses in liquid and dried states. In particular, formulations include Rotavirus preparations with excess Ca2+ and high viscosities that ensure infective potency at elevated temperatures. Methods include bulk purification of Rotavirus from cell culture and administration of formulations as vaccines including components for gastric neutralization.
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