Enzyme-catalyzed synthesis of site-specific and stoichiometric biomolecule-polymer conjugates

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专利权人:

Duke University

发明人:

Ashutosh Chilkoti,Yizhi Qi

申请号：

US14894731

公开号：

US09592303B2

申请日:

2014.05.30

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the C-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.

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