ENZYME-CATALYZED SYNTHESIS OF SITE-SPECIFIC AND STOICHIOMETRIC BIOMOLECULE-POLYMER CONJUGATES

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专利权人:

Duke University

发明人:

Ashutosh Chilkoti,Yizhi Qi

申请号：

US15945696

公开号：

US20180221496A1

申请日:

2018.04.04

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the polypeptide using a sortase enzyme and in situ polymerization of a polymer from the C-terminus. The polypeptide-polymer conjugates may have desirable pharmacological properties and may be used therapeutically.

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中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/