PLASMIDE RECOMBINANT A CODON OPTIMISE CODANT VEGF ET FGF-E ET METHODES DE STIMULATION DE LA REGENERATION DU NERF PERIPHERIQUE ET TRAITEMENT DE DOMMAGE NERVEUX CHEZ LES HUMAINS
ISAEV, ARTUR ALEKSANDROVICH,RIZVANOV, ALBERT ANATOLYEVICH,MASGUTOV, RUSLAN FARIDOVICH,BOGOV, ALEKSEI ANDREEVICH,SALAFUTDINOV, ILNUR ILDUSOVICH,DEEV, ROMAN VADIMOVICH,BOZO, ILYA YADIGEROVICH,PLAKSA, IG
申请号：
CA2960371
公开号：
CA2960371A1
申请日:
2015.08.27
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention relates to medicine, and more particularly to neurosurgery and trauma surgery, and can be used for stimulating nerve regeneration through the use of a gene therapeutic construct which codes for vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF-2). The gene therapeutic construct that codes for the two factors is based on a codon-optimized recombinant plasmid. The gene therapeutic construct can be introduced either directly into a damaged nerve or into the perineural tissues either during surgery or in the post-operative period. The invention significantly improves the outcomes of the reconstructive treatment of damaged peripheral nerves.
