Novel Polypeptides That Bound to IL-23 Receptor and Inhibit Binding of IL-23 and Cell Signaling Thereof

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专利权人:

Grant Gallagher;Raymond Yu;Jonathan Brazaitis

发明人:

Grant Gallagher,Raymond Yu,Jonathan Brazaitis

申请号：

US13523286

公开号：

US20130029907A1

申请日:

2012.06.14

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention relates to novel polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The novel polypeptides of the present invention has a core structure of WX1X2X3W, where W is tryptophan, and X1, X2 and X3 are amino acids, with the proviso that when one of X1, X2 or X3 is W, the remaining two of X1, X2 or X3 cannot be W. The present invention relates a composition containing the novel polypeptides, and use of same in treating IL-23 associated human diseases including, for example, inflammatory bowel diseases, psoriasis and Crohn's disease.

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