A topical anti-parasitic composition comprising: (i) from about 0.001% w/v to about 15% w/v of at least one avermectine, based on the total weight of the composition； (ii) at least about 60% w/v of a solvent, based on the total weight of the composition； and (iii) at least one oil in an amount of up to about 30 % w/vl based on the total weight of the composition, where in the composition is free of polymeric material.
