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Sulfonyl-piperidine derivatives and their use to treat procineticin-mediated diseases
专利权人:
Takeda Pharmaceutical Company Limited
发明人:
CARROLL, Colm,GOLDBY, Anne,TEALL, Martin
申请号:
ES13728238
公开号:
ES2671629T3
申请日:
2013.05.29
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of formula (Ia) or a pharmaceutically acceptable salt thereof wherein W1, X1, Y1 and Z1 each independently represent N, NH or CH, wherein at least two of W1, X1, Y1 and Z1 represent N or NH ; p is 0, 1, 2 or 3; each R11 independently represents halogen, cyano, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 alkylthio, (C1-C6 alkyl) -carbonyl, or C1-C6 alkyl optionally substituted with carboxyl or (C1 alkoxy -C6) -carbonyl; q is 0, 1, 2, 3 or 4; each R12 independently represents halogen, cyano, carboxyl, hydroxyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, (C1-C6 alkoxy) -carbonyl, (C1-C6 alkoxy) - (alkyl C1-C6) or a 5- to 9-membered heterocyclic ring system; R13 represents an oxygen atom or a group C>; = O, NR15 or CR16R17, with the proviso that (i) when R13 represents CO or NH and ring A represents pyrazol-4-yl or imidazol-4-yl, then p must be 3 and R14 represents a substituted phenyl, pyridinyl or naphthyl ring system, and (ii) when R13 represents CH2 and ring A represents pyrazol-4-yl or imidazol-4-yl, then either p is 3 , or, p is 2 and q is at least 1; R15 represents a hydrogen atom or a C1-C6 alkyl group; R16 and R17 each independently represent a hydrogen or halogen or cyano atom, carboxyl, hydroxyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, (C1-C6 alkoxy) -carbonyl, ( C1-C6 alkoxy) - (C1-C6 alkyl) or a 5- to 9-membered heterocyclic ring system; R14 represents a phenyl, pyridinyl or naphthyl ring system, the ring system itself being optionally substituted with at least one substituent selected from halogen, hydroxyl, cyano, oxo, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl , C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, (C1-C6 alkyl) -carbonyl, (C1-C6 alkyl ) -carbonyloxy, (C1-C6 alkoxy) -carbonyl, amino, -CON (R18) 2, (C1-C6 alkyl) amino, di- (C1-C6 alkyl) amino, C3-C6 cycloalkyl, C3-C6 cycloalkyloxy or (C3-C6 cycloalk
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