GUCKIAN, Kevin,KUMARAVEL, Gnanasambandam,MA, Bin,SUN, Lihong,XIN, Zhili,ZHANG, Lei
申请号：
ES13828421
公开号：
ES2660287T3
申请日:
2013.08.05
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound represented by structural formula (II) or (III): ** Formula ** or a pharmaceutically acceptable salt thereof, where: "------" indicates a double bond； A1, A2, A3, A4, A5, A6 and A7 are CR2； X is O； R1 is a C6-20 alkyl, a C3-14 carbocyclyl, a 3-15 membered heterocyclyl, or a 5-14 membered heteroaryl, wherein the heterocyclyl and heteroaryl comprise 1 to 10 heteroatoms independently selected from N, S or O, and where R1 may be optionally substituted with 1 to 6 independently selected R6； R2, for each occurrence, is independently selected from the group consisting of hydrogen, halogen, hydroxyl, nitro, cyano, carboxy, C1-6 alkyl, C1-6 halogenoalkyl, C3-8 cycloalkyl, C3-8 halogenocycloalkyl, C1- alkoxy 6, C1-6 halogenoalkoxy, C3-8 cycloalkoxy, C3-8 halogenocycloalkoxy, C1-6 alkanoyl, amino, N- (C1-6 alkyl) amino, N, N-di- (C1-6 alkyl) amino, C1 alkoxy -6-carbonyl, C1-6-oxy alkanoyl, carbamoyl, N- (C1-6 alkyl) carbamoyl, N, N-di- (C1-6 alkyl) carbamoyl, C1-6-amido alkyl, mercapto, C1- alkyl 6-thio, C1-6 alkyl sulfonyl, sulfamoyl, N- (C1-6 alkyl) sulfamoyl, N, N-di- (C1-6 alkyl) sulfamoyl and C1-6 alkyl sulfonamido； R5 is a C1-6 alkylene, C3-8 carbocyclyl, 3 to 8 membered heterocyclyl, C6-10 aryl, 5 to 10 membered heteroaryl, a bridge ring system comprising 6 to 12 ring members, a system spiro ring comprising 5 to 14 ring members or a bicyclic ring system represented by the following formula: ** Formula ** where B 'and B "are independently selected from the group consisting of monocyclic C3-8 carbocyclyl, a monocyclic 3- to 8-membered heterocyclyl, phenyl or a 5- to 6-membered heteroaryl； where R5 may be optionally substituted with 1 to 4 independently selected R11； R6, for each occurrence, is independently selected from the group consisting of halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 halogenoalkyl, C3-8 cycloalkyl, C6-10 aryl, C1-6 alkoxy-C1-6 alkyl and tri (C1-6 alkyl) silyl； or two R6 which are linked with the same carbon atom they can form C3-8 spirocycloalky
