A device for treatments of endoscopic resection/removal of tissues, includes:a hand-piecean outer tubular element extending along a longitudinal axis having a proximal end, a distal end, and a cutting aperture at the distal endan inner tubular element housed in rotation in the outer tubular element the inner tubular element extending along the longitudinal axis and having a proximal end, a distal end and a cutting tip at its distal endguiding elements including an electric motor and electric supply to rotate and/or oscillate the inner tubular element with respect to the outer tubular elementa first engagement keyed substantially at the proximal end of the inner tubular elementa second engagement keyed on the distal end of the motors outlet shaft to axially slide theron andat least one spring element to push the second engagement in engagement with the first engagement.