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INJECTION EMULSION OF SEDATIVE CURRICULAR AGENT
专利权人:
АстраЗенека АБ (SE)
发明人:
БУТ Джонатан (GB),ДИКСОН Лейх (GB),ВАШИНГТОН Клайв (GB)
申请号:
RU2012144777/15
公开号:
RU2012144777A
申请日:
2011.05.12
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. An injection emulsion containing: a compound representing a substituted phenylacetic acid ester; a water-immiscible solvent; emulsifier; tonicity modifier; iodine; and optionally containing one or more of the following components selected from a pH buffering agent, stabilizer and excipient; wherein the pH of the emulsion is more than about 7; where the average emulsion droplet size is less than about 200 nm. 2. The emulsion according to claim 1, wherein said substituted phenylacetic acid ester is present in an amount of from about 0.25 wt.% To about 25 wt.%. 3. The emulsion according to claim 1 or 2, wherein said substituted phenylacetic acid ester is present in an amount of from about 0.25 wt.% To about 15 wt.%. 4. The emulsion according to claim 1, wherein said substituted phenylacetic acid ester is present in an amount of from about 1 wt.% To about 10 wt.%. The emulsion according to claim 1, wherein said substituted phenylacetic acid ester is [3-ethoxy-4 - [(N, N-diethylcarbamido) methoxy] phenyl] acetic acid n-propyl ester. The emulsion according to claim 1, wherein the water-immiscible solvent is present in an amount of from about 0.1 wt.% To about 50 wt.%. The emulsion according to claim 1, wherein the water-immiscible solvent is present in an amount of from about 5 wt.% To about 15 wt.%. The emulsion according to claim 1, wherein the water-immiscible solvent is a vegetable oil, animal oil, medium chain triglyceride, long chain triglyceride or semi-synthetic oil. The emulsion according to claim 1, where the water-immiscible solvent is1. Инъекционная эмульсия, содержащая:соединение, представляющее собой замещенный эфир фенилуксусной кислоты;не смешивающийся с водой растворитель;эмульгатор;модификатор тоничности; иводу;и возможно дополнительно содержащая один или более чем один из следующих компонентов, выбранных из буферного агента для регулирования pH, стабилизатора и вспомогательного вещества;где pH эмульсии составляет более чем примерно 7; игде средний ра
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