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Injectable preparations of diclofenac and its pharmaceutically acceptable salts
专利权人:
Milan Rajnibhai Patel;Ketan Rajnibhai Patel
发明人:
Ketan Rajnibhai Patel,Milan Rajnibhai Patel
申请号:
US11883331
公开号:
US08809393B2
申请日:
2006.01.30
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention provides injectable formulations of water-soluble salts of diclofenac in single doses of less than 2 ml, which cause significantly less pain at the site of injection and can be administered by intradeltoid route, in addition to intragluteal and slow intravenous route. More specifically the injectable preparations contain 75 mg to 100 mg of water-soluble salts of diclofenac, in about 1 ml injection solution without significantly raising the viscosity of the injection solution without the use surfactants. The formulations are adjusted to pH 6 to 10 containing up to 100 mg of diclofenac salt in a medium comprising of water, along with one or more co-solvent(s)/solubilizer(s), antioxidants, preservatives, buffers, alkali and stabilizers.
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