The present invention provides a glucan and mushroom polysaccharide composition, which contains 20-50 wt% of beta-glucan concentrate, 20-50 wt% of ganoderma lucidum mycelium extract, 1-5 wt% of antrodia camphorate mycelium extract, 1-5 wt% of cordyceps sinensis mycelium extract, 1-5 wt% of phellinus linteus fruiting body extract, 1-5 wt% of agaricus blazei mrill fruiting body extract, 1-5 wt% of grifola frondosa fruiting body extract, and 1-5 wt% of hericium erinaceus fruiting body extract.一種葡聚醣及菇蕈多醣體組成物,包含以重量百分比計為20至50%之一β-聚葡萄糖濃縮液、重量百分比20至50%之一靈芝菌絲體萃取液、重量百分比1至5%之一牛樟芝菌絲體萃取液、重量百分比1至5%之一冬蟲夏草菌絲體萃取液、重量百分比1至5%之一桑黃子實體萃取液、重量百分比1至5%之一巴西蘑菇子實體萃取液、重量百分比1至5%之一舞茸子實體萃取液以及重量百分比1至5%之一猴頭菇子實體萃取液。