Xing Cheng,Danielle Carroll,Matthew McCourt,Mark Galinski,Hong Jin
申请号：
US14916102
公开号：
US10519426B2
申请日:
2014.09.02
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides methods for inducing regression of tumors in human subjects, the methods utilize a modified mesogenic strain of Newcastle disease virus (NDV) with modified F protein cleavage site, which is non-pathogenic to poultry (lentogenic), but exhibits oncolytic properties. The disclosed methods provide safe, effective and reliable means to induce regression of a tumor in an individual in need thereof. These methods overcome the drawbacks of using pathogenic strains of viruses for human therapy.
