Xing CHENG,Danielle CARROLL,Matthew MCCOURT,Mark GALINSKI,Hong JIN
申请号：
US16684241
公开号：
US20200181581A1
申请日:
2019.11.14
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides methods for inducing regression of tumors in human subjects, the methods utilize a modified mesogenic strain of Newcastle disease virus (NDV) with modified F protein cleavage site, which is non-pathogenic to poultry (lentogenic), but exhibits oncolytic properties. The disclosed methods provide safe, effective and reliable means to induce regression of a tumor in an individual in need thereof. These methods overcome the drawbacks of using pathogenic strains of viruses for human therapy.
