WILLINGHAM, STEPHEN,MILLER, RICHARD A.,HO, PO Y.,MCCAFFERY, IAN,HOTSON, ANDREW
申请号：
CA3009527
公开号：
CA3009527A1
申请日:
2016.12.22
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Provided herein are, inter alia, methods of treating cancer by administering to a subject a therapeutically effective amount of an adenosine-A2A(A2A) receptor antagonist or a combination of an adenosine-A2A(A2A)receptor antagonist and a programmed cell death protein 1(PD-1) signaling pathway inhibitor. Further provided are pharmaceutical compositions including an A2Areceptor antagonist, a PD-1 signaling pathway inhibitor and a pharmaceutically acceptable excipient. Further provided are methods of detecting cellular effects,for example expression of pCREB, before, after or during adenosine receptor antagonist treatment.
