Fundacion Centro Nacional de Investigaciones Oncologicas Carlos III
发明人:
Soengas Gonzalez, Maria Soledad,Tormo Carulla, Damia
申请号：
AU2010270291
公开号：
AU2010270291A1
申请日:
2010.07.05
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Process for the identification of compounds for treating cancer. The invention relates to a method for identifying candidate compounds for use as therapeutic agents for the treatment of cancer, among those who are able to activate the MDA-5 protein or increase NOXA protein levels and to trigger autophagy. It is based on the fact that activation of dsRNA sensor MDA-5 is able to trigger the destruction of cancer cells by activation both autophagy and apoptosis, autonomously and selectively in tumor cells, without provoking the stabilization of the natural antagonist NOXA, MCL-I. The invention also relates to the use of double-stranded RNAs of the same or similar nature such as polyinosinic-polycytidylic acid (pIC), complexed with carriers such as polyethylenimine poly cation (PEI), for the manufacture of medicines for the treatment of cancer.
