您的位置: 首页 > 农业专利 > 详情页

Process for the identification of compounds for treating cancer
专利权人:
Fundacion Centro Nacional de Investigaciones Oncologicas Carlos III
发明人:
Soengas Gonzalez, Maria Soledad,Tormo Carulla, Damia
申请号:
AU2010270291
公开号:
AU2010270291A1
申请日:
2010.07.05
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
Process for the identification of compounds for treating cancer. The invention relates to a method for identifying candidate compounds for use as therapeutic agents for the treatment of cancer, among those who are able to activate the MDA-5 protein or increase NOXA protein levels and to trigger autophagy. It is based on the fact that activation of dsRNA sensor MDA-5 is able to trigger the destruction of cancer cells by activation both autophagy and apoptosis, autonomously and selectively in tumor cells, without provoking the stabilization of the natural antagonist NOXA, MCL-I. The invention also relates to the use of double-stranded RNAs of the same or similar nature such as polyinosinic-polycytidylic acid (pIC), complexed with carriers such as polyethylenimine poly cation (PEI), for the manufacture of medicines for the treatment of cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充