PROCESS FOR THE IDENTIFICATION OF COMPOUNDS FOR TREATING CANCER
- 专利权人:
- 发明人:
- SOENGAS GONZALEZ MARIA SOLEDAD,TORMO CARULLA DAMLA
- 申请号：
- IN216/MUMNP/2012
- 公开号：
- IN2012MN00216A
- 申请日:
- 2012.01.27
- 申请国别(地区):
- IN
- 年份:
- 2012
- 代理人:
- 摘要：
Process for the identification of compounds for treating cancer. The invention relates to a method for identifying candidate compounds for use as therapeutic agents for the treatment of cancer, among those who are able to activate the MDA-5 protein or increase NOXA protein levels and to trigger autophagy. It is based on the fact that activation of dsRNA sensor MDA-5 is able to trigger the destruction of cancer cells by activation both autophagy and apoptosis, autonomously and selectively in tumor cells, without provoking the stabilization of the natural antagonist NOXA, MCL-I. The invention also relates to the use of double-stranded RNAs of the same or similar nature such as polyinosinic-polycytidylic acid (pIC), complexed with carriers such as polyethylenimine poly cation (PEI), for the manufacture of medicines for the treatment of cancer.
[WO2011003883A1]
- 来源网站：
- 中国工程科技知识中心
