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DERIVES DE QUINUCLIDINE ET LEUR UTILISATION COMME LIGANDS DES RECEPTEURS M3 MUSCARINIQUES
- 专利权人:
- ALMIRALL; S.A.
- 发明人:
- 申请号:
- EP00951361.5
- 公开号:
- EP1200431B3
- 申请日:
- 2000.07.07
- 申请国别(地区):
- EP
- 年份:
- 2015
- 代理人:
- 摘要:
- A compound according to formula (I) wherein: <;custom-character file="US20030055080A1-20030320-P00900.TIF" wi="20" he="20" id="custom-character-00001"/>;is a phenyl ring, a C4 to C9 heteroaromatic compound containing one or more heteroatoms, or a naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl or biphenyl group; R1, R2 and R3 each independently represent a hydrogen or halogen atom, or a hydroxy group, or a phenyl, -OR4, -SR4, -NR4R5, -NHCOR4, -CONR4R5, -CN, -NO2, -COOR4 or -CF3 group, or a straight or branched lower alkyl group which may optionally be substituted, for example, with a hydroxy or alcoxy group, wherein R4 and R5 each independently represent a hydrogen atom, straight or branched lower alkyl group, or together form an alicyclic ring; or R1 and R2 together form an aromatic, alicyclic or heterocyclic ring; n is an integer from 0 to 4; A represents a -CH2-, -CH=CR6, -CR6=CH-, -CR6R7-, -CO-, -O-, -S-, -S(O)-, SO2 or -NR6- group, wherein R6 and R7 each independently represent a hydrogen atom, straight or branched lower alkyl group, or R6 and R7 together form an alicyclic ring; m is an integer from 0 to 8; provided that when m=0, A is not -CH2-; p is an integer from 1 to 2 and the substitution in the azoniabicyclic ring may be in the 2, 3 or 4 position including all possible configurations of the asymmetric carbons; B represents a group of formula i) or ii): wherein R10 represents a hydrogen atom, a hydroxy or methyl group; and R8 and R9 each independently represents wherein R11 represents a hydrogen or halogen atom, or a straight or branched lower alkyl group and Q represents a single bond, -CH2-, -CH2-CH2-, -O-, -O-CH2-, -S-, -S-CH2- or -CH=CH-, and when i) or ii) contain a chiral centre they may represent either configuration; X represents a pharmaceutically acceptable aL'invention concerne un composé correspondant à la formule (I) dans laquelle z© représente un noyau phényle, un composé hétéroaromatique C4-C9 contenant un ou plusieurs hétéroatomes, o
- 来源网站:
- 中国工程科技知识中心
- 来源网址:
- http://www.ckcest.cn/home/