A system and method for multi-modality fusion for 3D printing of a patient-specific organ model is disclosed. A plurality of medical images of a target organ of a patient from different medical imaging modalities are fused. A holistic mesh model of the target organ is generated by segmenting the target organ in the fused medical images from the different medical imaging modalities. One or more spatially varying physiological parameter is estimated from the fused medical images and the estimated one or more spatially varying physiological parameter is mapped to the holistic mesh model of the target organ. The holistic mesh model of the target organ is 3D printed including a representation of the estimated one or more spatially varying physiological parameter mapped to the holistic mesh model. The estimated one or more spatially varying physiological parameter can be represented in the 3D printed model using a spatially material property (e.g., stiffness), spatially varying material colors, and/or spatially varying material texture.
