PURPOSE: A composition is provided to suppress NO generation without cytotoxicity, to suppress airway resistance, inflammatory materials, lung tissue protein STAT4 and STAT6, and T cell activation, and to increase anti-inflammatory materials. CONSTITUTION: A composition for preventing and treating bronchial asthma contains a mixture extract of Rehmannia glutinosa, Pinellia ternate, Citrus reticulate, Glycyrrhiza glabra, Platycodon grandiflorum, and Schizandra chinensis as an active ingredient. The mixture extract is prepared using 70% methanol. The daily dose of the mixture extract is 0.0001-10 mg/kg. A health functional food for preventing and treating bronchial asthma contains the mixture extract as an active ingredient. The health functional food further contains a sitologically acceptable food additive. [Reference numerals] (AA) Extraction with water, OMC 0.1mg/kg + OVA； (BB) Extraction with water, OMC 1mg/kg + OVA； (CC) Extraction with methanol, OMC 0.1mg/kg + OVA； (DD) Extraction with methanol, OMC 1mg/kg + OVA본 발명은 숙지황(熟地黃, Rehmanniaglutinosa), 반하(半夏,Pinellia ternata), 진피(陳皮, Citrusreticulata), 감초(甘草, Glycyrrhizaglabra), 길경(桔梗, Platycodongrandiflorum), 오미자(五味子, Schizandrachinensis) 혼합 추출물을 유효성분으로 함유하는 기관지 천식의 예방과 치료를 위한 조성물에 및 건강기능식품에 관한 것이다.본 발명에 따른 조성물은 세포 독성이 없고 NO 생성을 억제하며, 기관지 조직의 치료, 기도저항의 억제, 염증성 물질의 억제, 항염증성 물질의 증가, T 세포 활성화 억제, 폐조직 단백질 STAT4 및 STAT6의 억제 및 간독성이 없는 효과를 보유하고 있다.
