The present invention relates to a device, system and a method for extracting physiological information indicative of at least one vital sign of a subject. To provide a high motion robustness, the proposed device comprises an input interface (30) for obtaining at least two detection signals (Cn) derived from detected electromagnetic radiation transmitted through or reflected from a skin region of a subject, wherein each detection signal comprises wavelength-dependent reflection or transmission information in a different wavelength channel, a pulse signal computation unit (32) for computing at least two pulse signals (S1, S2) from said at least two detection signals (Cn) using different signature vectors (Pbv1, Pbv2) for the computation of each pulse signal, a quality indicator computation unit (34) for computing quality indicator values (Q1, Q2) for said pulse signals (S1, S2) indicating a characteristic of the respective pulse signal, and a processing unit (38) for deriving physiological information (V) indicative of at least one vital sign from the signature vector that results in the pulse signal with the best quality indicator value (Q1, Q2) and/or from said pulse signal.
