DUMBLE, MELISSA,GILMER, TONA,KUMAR, RAKESH,LEBOWITZ, PETER F.,MORRIS, SHANNON RENAE,LAQUERRE, SYLVIE
申请号:
MX2012003546
公开号:
MX2012003546A
申请日:
2010.09.23
申请国别(地区):
MX
年份:
2012
代理人:
摘要:
The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethy l-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl ]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and N-{(1 S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl}-5-chloro-4-(4-c hloro-1-methyl-1 H-pyrazol-5-yl)-2-furancarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.La presente invención se refiere a un método para tratar cáncer en un humano y a las combinaciones farmacéuticas útiles en tal tratamiento; en particular, el método se refiere a un método de tratamiento de cáncer que incluye administrar N-{3-[3-ciclopropil-5-(2-fluoro-4-yodo-fenilamino)-6,8-dimetil-2, 4,7-trioxo-3,4,6,7-tetrahidro-2H-pirido[4,3-d]pirimidin-1-il]feni l}acetamida, o una sal o solvanto farmacéuticamente aceptable de la misma, y N-{(1S)-2-amino-1-[(3,4-difluorofenil)metil]etil}-5-cl oro-4-(4-cloro-1-metil-1H-pirazol-5-il)-2-furancarboxamida, o una sal farmacéuticamente aceptable de la misma a un humano que lo necesita.