FIELD: medicine, pharmaceutics.SUBSTANCE: in the general formula (I), R1 is specified in cyano, (2-4C)alkynyl, (1-4C)alkyl, (3-6C)cycloalkyl, (4-6C)cycloalkenyl, (6-8C)bicycloalkyl, (8-10C)bicyclic group, each of which can be substituted by (1-4C)alkyl, phenyl, biphenyl, naphthyl each of which can be substituted by three substitutes independently specified in halogen, (1-4C)alkyl substituted as may be necessary by one or more atoms of fluorine, (2-4C)alkynyl, (1-4C)alkoxy substituted as may be necessary by one or more atoms of fluorine, amino, di(1-4C)alkylamino and (3-6C)cycloalkyl, phenyl substituted by phenoxy, benzyl, benzyloxy, phenylethyl or a monocyclic heterocycle, each of which can be substituted by (1-4C)alkyl, 5-6-merous monocyclic heterocycle containing 1-3 heteroatoms specified in N, O and S substituted as may be necessary by a halogen, (1-4C)alkyl or phenyl substituted as may be necessary by (1-4C)alkyl, and 9-10-merous bicyclic heterocycle containing 1-2 heteroatoms specified in N and O substituted as may be necessary by (1-4C)alkyl A is specified in -CO-O-, -NH-CO-, -CO-NH, -C=C-, -CCH-O- and a binding group -Y-(CH)-X-, wherein Y is attached to R1 and specified in a bond, -O-, -SO-, -CH-O-, -CO-, -CO-O-, -CO-NH-, -NH-CO-, -C=C- and -C?C- n means an integer from 1 to 7 and X is attached to a phenylene group and specified in a bond, -O-, -S-, and -NH the ring structure B represents phenylene R2 means H, (1-4C)alkyl substituted as may be necessary by one or more atoms of fluorine, (1-4C)alkoxy or halogen and R3 means (1-4C)alkylene-R5, wherein the alkylene group can be substituted by one or more atoms of a halogen, or R3 means (3-6C)cycloalkylene-R5 or -CO-CH-R5, wherein R5 means -OH, -POH, -OPOH, -COOH or tetrazol-5-yl R4 means H or (1-4C)alkyl R6 means one or more substitutes independently specified in H, (1-4C)alkyl or oxo W means -O- or -S-.EFFECT: invention refers to (thio)morpholine derivatives of formula (I) possessing the property of a sphingosi
