Christopher Bieniarz,Jennifer Wong,Mark Lefever,Jerome W. Kosmeder, II,Julia Ashworth-Sharpe,Casey A. Kernag
申请号：
US14146389
公开号：
US09315789B2
申请日:
2014.01.02
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled probes can be accomplished using the disclosed conjugates as a primary antibody without amplification.
