Christopher Bieniarz,Jerome W. Kosmeder,Mark Lefever,Casey A. Kernag,Julia Ashworth-Sharpe,Jennifer Wong
申请号：
US15064792
公开号：
US20160187324A1
申请日:
2016.03.09
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled probes can be accomplished using the disclosed conjugates as a primary antibody without amplification.
