PROBLEM TO BE SOLVED: To provide a method of manufacturing a medical transdermal absorption sheet with which the drying time of the base liquid can be reduced.SOLUTION: The method of manufacturing a medical transdermal absorption sheet includes, in the order of description: a filtration step of aseptically filtering a base liquid 24； a base liquid feeding step of feeding the base liquid 24 to a surface of a mold 13 having needle-like recessed portions, tip ends of which are filled with a drug solution, while forming a space between the drug solution and the base liquid； a drying step of drying the drug solution and the base liquid 24； and a peeling-off step of peeling off a medical transdermal absorption sheet formed by drying the drug solution and the base liquid 24. An average concentration of solid content of the base liquid in the drying step is increased by 5% or more from the average concentration of solid content of the base liquid in the base liquid feeding step, and then in a state in which the average concentration of solid content is 75% or less, the base liquid 24 is moved into the needle-like recessed portions of the mold 13.SELECTED DRAWING: Figure 23【課題】基材液の乾燥時間を短縮することができる医療用経皮吸収シートの製造方法を提供する。【解決手段】基材液２４を無菌ろ過するろ過工程と、針状凹部を有し、針状凹部の先端に薬液が充填されたモールド１３の針状凹部が形成された面上に、薬液との間に空間を空けて基材液２４を供給する基材液供給工程と、薬液および基材液２４を乾燥する乾燥工程と、薬液および基材液２４を乾燥することで形成された医療用経皮吸収シートを剥離する剥離工程と、を順に有し、乾燥工程で、基材液の平均固形分濃度を基材液供給工程における基材液の平均固形分濃度から５％以上増加させた後、平均固形分濃度が７５％以下の状態で、基材液２４をモールド１３の針状凹部内に移動させる医療用経皮吸収シートの製造方法である。【選択図】図２３
