PROBLEM TO BE SOLVED: To provide a method of producing a transdermal absorption sheet which is less likely to wrinkle and has well shaped needle-like projected portions.SOLUTION: The method is comprised of the following steps in the order of description: a polymer solution filling step of filling needle-like recessed portions 15 on a mold 13 having the needle-like recessed portions 15 with a polymer solution 24； a polymer solution drying step of drying the filled polymer solution 24 to form a polymer layer； and a peeling step of peeling off the polymer layer. The polymer solution drying step is characterized in that the polymer solution is dried at a lower rate in a concentration range of polymer solution average solid content concentration being 70 wt.% or more and 80 wt.% or less, and with a constant drying rate of water as an index, the constant drying rate in the concentration range of polymer solution average solid content concentration being 70 wt.% or more and 80 wt.% or less is slower than the maximum value of constant drying rate in concentration range of polymer solution average solid content concentration being less than 70 wt.% and more than 80 wt.%.SELECTED DRAWING: Figure 12【課題】シワの発生を抑制し、針状凸部の形状が良好な経皮吸収シートの製造方法を提供する。【解決手段】針状凹部１５を有するモールド１３の針状凹部１５にポリマー溶解液を充填するポリマー溶解液充填工程と、充填されたポリマー溶解液を乾燥させて、ポリマー層を形成するポリマー溶解液乾燥工程と、ポリマー層を剥離する剥離工程と、をこの順で備え、ポリマー溶解液乾燥工程は、ポリマー溶解液の平均固形分濃度が７０ｗｔ％以上８０ｗｔ％以下の濃度範囲で低速乾燥条件とし、水の定率乾燥速度を指標とした際に、ポリマー溶解液２４の平均固形分濃度が７０ｗｔ％以上８０ｗｔ％以下の濃度範囲で、定率乾燥速度が、ポリマー溶解液２４の平均固形分濃度が７０ｗｔ％未満、および、８０ｗｔ％を超える濃度範囲の乾燥条件における定率乾燥速度の最大値より遅くする。【選択図】図１２
