As for this invention, general formula (i)For example the isoxazole 5 karubokisamido derivative which it possesses or the salt which that medicine can be allowed, TRPV1 mediation obstacle of the medicine composition, and the aforementioned isoxazole 5 karubokisamido derivative which include that (, acuteness and chronicity painfully obstacle, acuteness and chronic nervous obstacle characteristic painful, acuteness and chronic inflammation characteristic painfully, the breathing apparatus disease and lower part urine road obstacle) it regards the use in order to remedy.本発明は、一般式(I)を有するイソオキサゾール-5-カルボキサミド誘導体またはその医薬的に許容され得る塩、それを含む医薬組成物、及び前記イソオキサゾール-5-カルボキサミド誘導体のTRPV1媒介障害(例えば、急性及び慢性疼痛障害、急性及び慢性神経障害性疼痛、急性及び慢性炎症性疼痛、呼吸器疾患及び下部尿路障害)を治療するための使用に関する。
