Zhou, Han-Jie,Sun, Congcong M.,Shenk, Kevin D.,Laidig, Guy J.
申请号：
LT13157801
公开号：
LT2623113T
申请日:
2006.11.09
申请国别(地区):
LT
年份:
2017
代理人:
摘要：
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. Oral administration of these peptide-based proteasome inhibitors is possible due to their bioavailability profiles.
