ZHOU, HAN-JIE,SUN, CONGCONG, M.,SHENK, KEVIN, D.,LAIDIG, GUY, J.
申请号：
MYPI 20081524
公开号：
MY145757A
申请日:
2006.11.09
申请国别(地区):
MY
年份:
2012
代理人:
摘要：
PEPTIDE-BASED COMPOUNDS INCLUDING HETEROATOM-CONTAINING, THREE-MEMBERED RINGS EFFICIENTLY AND SELECTIVELY INHIBIT SPECIFIC ACTIVITIES OF N-TERMINAL NUCLEOPHILE (NTN) HYDROLASES ASSOCIATED WITH THE PROTEASOME. THE PEPTIDE-BASED COMPOUNDS INCLUDE AN EPOXIDE OR AZIRIDINE, AND FUNCTIONALIZATION AT THE N-TERMINUS. AMONG OTHER THERAPEUTIC UTILITIES, THE PEPTIDE-BASED COMPOUNDS ARE EXPECTED TO DISPLAY ANTI-INFLAMMATORY PROPERTIES AND INHIBITION OF CELL PROLIFERATION. ORAL ADMINISTRATION OF THESE PEPTIDE-BASED PROTEASOME INHIBITORS IS POSSIBLE DUE TO THEIR BIOAVAILABILITY PROFILES.
