PROBLEM TO BE SOLVED: To provide a technique for organ regeneration suitable for industrial use using inducible pluripotent stem cells (iPS cells) that can be easily produced, specifically a technique for reproducing the "own organ" from somatic cells such as skin according to personal characteristics.SOLUTION: The present invention provides a method for producing an organ or body part of interest derived from a heterologous mammal of an individual different from a non-human mammal in a living body of the nonhuman mammal having an abnormality in which generation of the organ or body part of interest does not occur in a development stage. The method comprises the steps of: (a) preparing induced pluripotent stem cells (iPS cells) derived from the heterologous mammal； (b) transplanting the cells into a fertilized egg in a blastocyst stage of the non-human mammal； (c) developing the fertilized egg in the mother's womb of the non-human mammal to obtain offspring； and (d) acquiring the organ or body part of interest from the offspring individual. The iPS cell and the non-human mammal are originated from different species.SELECTED DRAWING: None【課題】簡便に作製可能な誘導型多能性幹細胞（ｉＰＳ細胞）を用いて産業用に適する臓器再生の技術すなわち個人の特性に応じて皮膚等の体細胞から、「自分自身の臓器」を再生する技術の提供。【解決手段】発生段階において目的臓器又は身体部分の発生が生じない異常を有する非ヒト哺乳動物の生体内において、該非ヒト哺乳動物とは異なる個体の異個体哺乳動物由来の該目的臓器又は身体部分を製造する方法であって、ａ）該異個体哺乳動物由来の誘導型多能性幹細胞（ｉＰＳ細胞）を調製する工程と、ｂ）該非ヒト哺乳動物の胚盤胞期の受精卵中に、該細胞を移植する工程と、ｃ）該受精卵を非ヒト仮親哺乳動物の母胎中で発生させて、産仔を得る工程と、ｄ）該産仔個体から、該目的臓器または身体部分を取得する工程と、を含み、前記ｉＰＳ細胞と前記非ヒト哺乳動物とが異種の関係のものである、目的臓器又は身体部分を製造する方法。【選択図】なし
