PROBLEM TO BE SOLVED: To provide an industrially-suitable technology for organ regeneration using an easily-producible induced pluripotent stem cell (iPS cell).SOLUTION: In a blastocyst complementation method, organ regeneration is performed by utilizing a fact that deficiency of an organ such as pancreas or the like is complemented by injecting an induced pluripotent stem cell (iPS cell) into a developed blastocyst. The method uses the iPS cell to manufacture, in a living body of a nonhuman mammal having abnormality not causing development of a target organ at a development stage, the target organ derived from a different individual mammal that is an individual different from the nonhuman mammal.COPYRIGHT: (C)2015,JPO&INPIT【課題】簡便に作製可能な誘導型多能性幹細胞(iPS細胞)を用いて産業用に適する臓器再生の技術を提供する。【解決手段】胚盤胞補完方法において、発生した胚盤胞に誘導型多能性幹細胞(iPS細胞)を注入することで、膵臓などの臓器の欠損を補われることを利用して、臓器再生を行う。発生段階において目的臓器の発生が生じない異常を有する非ヒト哺乳動物の生体内において、該非ヒト哺乳動物とは異なる個体の異個体哺乳動物由来の該目的臓器をiPS細胞を用いて製造する方法。【選択図】なし
