Compounds as EWS-FLI1 protein inhibitors are provided for use in treatment ofEwing'ssarcoma family tumours. A compound having a formula:wherein R1 is selected from the goup consisting of hydrogen, one amino acid,two amino acidslinked together and three amino acids linked together,R3, is selected from the group consisting of halogen, C1-6 alkoxy, ¨C(=O)NH2,¨NO2, and ¨OH； R6 is C1-6 dialkyl amine； R7 is selected from the groupconsisting of hydrogenand C1-6 alkyl； R8 is C1-6 alkyl； R4, R5, R9, R11, R12, and R14 areindependently selected from thegroup consisting of hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, ¨C(=O)NH2,¨NO2, ¨NH2, and ¨OH； R9, is selected from the group consisting of hydrogen, halogen, C1-6alkyl,¨C(=O)NH2, ¨NO2, ¨NH2, and ¨OH； R10 is halogen； R13, is selected from thegroup consisting ofhydrogen, halogen, C1-6 alkoxy, ¨C(=O)NH2, ¨NO2, ¨NH2, and ¨OH； and n is aninteger from 0to 4； with the proviso that R3 is not chlorine or fluorine when R1, R4, R5,R11, and R12 arehydrogen and R10 and R13 are chlorine.
