ASTRID DR. WENDT,ULRIKE DR. RHN,SUSANNE DR. RHRIG,ROBERT ALAN DR. WEBSTER,MARTINA VICTORIA DR. SCHMIDT,ADRIAN DR. TERSTEEGEN,KRISTIN DR. BEYER,MARTINA DR. SCHFER,ANJA DR. BUCHMLLER,CHRISTOPH DR. GERDE
申请号：
ARP140103539
公开号：
AR097756A1
申请日:
2014.09.24
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
From alternative phenylethylamine derivatives and procedures for the preparation of these substances, as well as their use in the production of drugs for the treatment and / or prevention of diseases, especially for the treatment of cardiovascular diseases and / or severe preoperative bleeding. Claim 1: consists of formula (1),Where R1 is a formula group (2) or (3),a. The polymerization point of nitrogen atom is 35, r8310 is 5-member heteromorphic body, in which the substitution of oxo, chlorine, cyanogen, hydroxyl and c833218331832323 tar can be used；In this case, one to three alternatives can be selected independently from the hydrofluorocarbon, amino compound, hydrofluorocarbon and thyroxine groups to replace asphalt, or in this case, one to seven alternatives can be used to replace asphalt, o. In the case that asphalt is replaced by a substitute selected from the group, the substitute is composed of hydroxyl, amino, hydrogen poisoning, thyroid, alcoxicobyl c833218331832424；1. Amino carbides and rental carbides c8332183313；e. In fluorine-containing substitutes 1-6, tar is further replaced； r831181 is hydrogen, fluorine or chlorine； r831222 and r8313, together with the carbon atoms connected with them, form five member different cycles, a. It can be replaced by one or two substitutes selected from the group of oxo, chlorine, cyanogen, hydroxyl, hydrogen poisoning and c8332183318333 asphalt independently；Pyridinediol and pyridinediene. In these two substances, asphalt can be replaced by 1 to 3 substitutes independently selected from hydroxyl group, amino group, hydrogen poisoning group and thyroid group, or in these two substances, asphalt can be replaced by 1 to 7 fluorine substitutes, o. In asphalt, it is replaced by substitutes composed of oxyhydrogen, amino group, hydrogen poisoning, thyroid, alcoxicorbyl c8332183331 and 8324242424；1. Amino carbides and rental carbides c8332183313；e. On the basis of fluorine-containing substitutes 1 to 6, asphalt was replaced b
