The present application relates to compounds derived from dihydropyrrolopyrimidine useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals. Claim 1: A compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein R¹ is hydrogen, methyl, CH₂OH, or -CH₂F； Y is 0 or 1； R² is hydrogen, cyano, C₁₋₃ alkyl,or -CF₃；R³ is hydrogen or C₁₋₃ alkyl；Ring A is C₃₋₈ cycloalkyl or 4-8 membered heterocycloalkyl； Q is -C (R⁹) (R¹⁰) -,-N (R¹¹) - or -O-；Each r8308； 749191 was selected from the groups of fluorine, cyanogen, oxo, methyl ch-8322；-CF8323,-CH₂OH, hydroxy and methoxy； R⁹ is hydrogen, fluorine, cyano, hydroxy, C₁₋₃ alkoxy,-S (O) R-O-S (O) R- [N (R²⁶)] ₕ-C (O) R³⁴,- N (R) -C (O) N (R) (R) - N (R) -C (O) OR-[n (No. 8313)] 8342； - S (o) 8322； - R3 8322；- N (R) -S (O) N (R) (R) o - N (R) -P (O) (CH)R¹⁰ is hydrogen, fluorine, or C₁₋₃ alkyl；R1 is hydrogen； - (CH 83222) 8346； - C (o) r8308； - 1,- (CH) q-C (O) N (R) (R) - (CH) -C (O) OR- (CH) -S (O) R- (CH) -S (O) N (R) (R) - (CH) -Ro -P (O) (CH)R8310,R83211；831222,8313,R y R cada uno son independientemente hidr geno o metilo h i j k l o p q r s t y u son cada uno independientemente 0 1 R es alquilo Cwherein the C₁₋₄-alkyl is optionally substituted by a substitute selected from the group consisting of fluorine, cyano, hydroxy, C₁₋₄-alkoxy,-NH832222,-NHCH₃,y -N (CH)R³³ is C₁₋₄ alkyl,-NH832222,-NHCH₃,-N (CH)or C₃₋₅ cycloalkyl,wherein the C₁₋₄-alkyl is optionally substituted by a substitute selected from the group consisting of fluorine, cyano, hydroxy, C₁₋₄-alkoxy,-NH832222,-NHCH₃,y -N (CH)R³⁴ and R⁴¹ are each independently hydrogen, C₁₋₄-alkyl,cycloalkyl C₃₋₆,4-6 membered heterocycloalkyl, or 5 membered heteroaryl, wherein C₁₋₄-alkyl,cycloalkyl C₃₋₆,and 4-6 membered heterocycloalkyl are each optionally substitut
