abstract disclosed are methods and related compositions for concomitantly, locally administering immunosuppressants and doses of therapeutic macromolecules for reducing type i and type iv hypersensitivity. "local and concomitant administration of tolerogenic synthetic nanocarriers to reduce type iv iv hypersensitivity" The present invention relates to methods and compositions related to the local and concomitant administration of immunosuppressants and doses of therapeutic macromolecules for reduce hypersensitivity of types ie iv.abstract disclosed are methods and related compositions for concomitantly, locally administering immunosuppressants and doses of therapeutic macromolecules for reducing type i and type iv hypersensitivity. tradução do resumo resumo patente de invenção: "administração local e concomitante de nanocarreadores sintéticos tolerogênicos para reduzir hipersensibilidade dos tipos i e iv" a presente invenção refere-se a métodos e composições relacionadas para a administração local e concomitante de imunossupressores e doses de macromoléculas terapêuticas para reduzir a hipersensibilidade dos tipos i e iv.
