Sean Matthew CLEVELAND,Stefan SALOMON,Cassandra VAN KRINKS
申请号：
US14422706
公开号：
US20150306058A1
申请日:
2013.08.21
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present disclosure provides a means of stabilising a single variable domain, in particular in protease-rich environments such as the stomach and intestine. A composition, in particular a pharmaceutical composition, comprising a single variable domain and camostat mesylate is provided, together with uses of said composition as a medicament and in methods of treatment. Compositions of the disclosure are particularly useful in the topical treatment of gastrointestinal conditions, such as Crohn's Disease or ulcerative colitis, or for direct activity in the gut mucosal immune system.
